The purpose of this study is to learn more about the effects of using oral nicotine pouches of different flavors and nicotine strengths in comparison to regular cigarettes. This is not a treatment study. We are currently enrolling healthy adults who smoke cigarettes and are at least 21 years old. You can earn up to $1030 for completing all portions of the study procedures.

Study participation will involve: 
 - A 2-hour screening evaluation to determine eligibility. 
-  If you are eligible, 7 drug testing sessions (lasting about 5 hours each) in the lab. Six of the 7 sessions require use of nicotine pouches of different nicotine strengths and flavors and the remaining session requires smoking of your usual brand of cigarettes.

All calls and participation related to this study are confidential: This survey will be collecting information about you. Your taking part in this survey is completely voluntary. Whether you join the study or not, the information collected today may be seen by researchers at Johns Hopkins, any sponsor of the study, and those responsible for oversight of the study. We try to make sure that the information we collect from you is kept private and used only for the research study we are discussing. The information we collect from you is kept confidential and used only for the research study we are discussing. If you do not agree to continue this survey, it will not affect your current or future care at Johns Hopkins. Your personal information will be kept if you choose not to enroll in the study or if you do not qualify to be in the study. This will be done so that we do not contact the same people twice.