Thank you for your interest in our study!

**PLEASE NOTE THAT THIS STUDY IS ON-SITE AT JOHNS HOPKINS BAYVIEW MEDICAL CAMPUS IN BALTIMORE, MARYLAND**

Reimbursement for travel costs may be available on a case-by-case basis, but is not guaranteed.
Hello and thank you for your interest in our kratom study!

Before you decide if you want to proceed with our screening questionnaire, which will help us determine if you may be eligible for the study, we want to tell you more about us and this study. This study is #IRB00408134

Who is conducting this study?
This study is being conducted by Dr. Kirsten Smith, a researcher in the Department of Psychiatry and Behavioral Sciences at Johns Hopkins University. Dr. Smith has been studying kratom since 2017.

What is this study about?
This study is not intended for people who are seeking treatment for kratom, rather this study is intended to measure how people who use kratom on a regular basis feel just after they use kratom and also how they feel when they suddenly stop using kratom. We are also interested in better understanding how kratom is processed by the body.
How do we assess this?
These effects will be studied by asking people to stay overnight with us for up to 3 consecutive days and 2 nights on a residential research unit and to complete questionnaires and tasks that will tell us whether they are experiencing any effects from their kratom and if they are experiencing any effects after they stop taking their kratom. To help understand how the body processes kratom, we will also collect blood and urine samples.

During the study, participants will consume a single serving/dose of the kratom product that they are currently regularly using at the dose that they are typically using under direct observation. After this single dose, no more kratom will be used during the study. By doing this we can measure effects both after kratom is used as well as after kratom use is stopped.

Where does this study take place?
The study takes place on the Johns Hopkins University Bayview Medical Center (JHBMC) campus at the Johns Hopkins Behavioral Pharmacology Research Unit (BPRU) and the Johns Hopkins Clinical Research Unit (CRU). The JHBMC is located in Baltimore, Maryland.
Would I be compensated for my study participation?
Participants will be compensated for completing study activities and may be reimbursed for some travel expenses on a case-by-case basis. The maximum study compensation for completing all study activities is $1,000.

What is the time commitment for this study?
This study requires a time commitment of a screening phone call, an in-person screening visit, and 3 consecutive full days/2 overnight stays in our residential research unit. The study days would be scheduled by a study team member with you in advance.

If you do not believe that you can participate for all study days, or that this time commitment would be a burden, then this study may not be right for you.

It is important that you understand the study details so you can decide whether to answer our screening questionnaire. However, please know that we will review all aspects of the study with you in detail at a future meeting if your responses today tell us you may be a good fit for the study. 
 
If you are still interested in the study and want to see if you may be eligible, then you will need to complete our screening questionnaire. Completing this questionnaire does not mean that you will be eligible. The purpose of this questionnaire is to determine if you may be eligible so that you can proceed to the next screening phase, which involves a phone call with a study team member.

PLEASE NOTE: this questionnaire may take up to 15 minutes to complete.

Before you begin, please make sure you are in a place where you feel comfortable and safe answering personal questions.
Would you like to answer questions to determine if you may be eligible for this study?